BIOGENIC AMINES, AMINO ACIDS AND REGIONAL BLOOD FLOW IN RAT BRAIN AFTER PRENATAL IRRADIATION
Damage to nerve cells after prenatal irradiation could affect their later ability to function normally. The concentration of several biogenic amines and amino acids was therefore determined at different times after prenatal irradiation with 0.95 Gy on day 10, 12 or 15 of pregnancy. The offspring was sacrificed 0.5, 1, 3 and 6 months after birth and the following structures were dissected: Cortex, hippocampus, striatum, thalamus, hypothalamus, cerebellum and medulla. Biogenic amines isolated by HPLC and detected electrochemically were: Dopamine, DOPA, DOPAC, epinephrine, norepinephrine, serotonin and hydroxyindolacetate. Amino acids converted to their dansyl derivatives and separated by HPLC were: Aspartate, glutamate, gamma aminobutyrate and taurine. Many neurotransmitters were found increased in brain after prenatal irradiation, particularly on day 12 and 15 p.C. Marked changes were found for serotonin in several brain structures and for dopamine in striatum. An increase was also found in glutamate, glutamine and GABA. Studies on regional blood flow using injection of labeled microspheres did not reveal significant alterations after prenatal irradiation.
Bibliographic Reference: SYMPOSIUM "RADIATION RISKS TO THE DEVELOPING NERVOUS SYSTEM", NEUHERBERG (GERMANY), JUNE 18-20, 1985 WRITE TO CEC LUXEMBOURG, DG XIII/A2, POB 1907 MENTIONING PAPER E 32326 ORA
Availability: Can be ordered online
Record Number: 1989124048500 / Last updated on: 1987-01-01
Available languages: en