SEROTONIN RECEPTORS, VASCULAR FUNCTIONS AND LIPIDS IN RAT BRAIN AFTER PRENATAL IRRADIATION
The changes in neurotransmitter concentration after prenatal irradiation observed earlier could also involve a modified binding capacity of corresponding receptors in the brain. Serotonin-2 receptors determined in cortex and striatum of one month old rats are increased after prenatal irradiation on day 12 or 15 but the binding constant is not changed. At an age of 3 months the changes are less conspicuous. The process of myelination as measured from the content of cholesterol, sphingomyelines, choline and ethanolamine containing phospholipids and gangliosides shows little alterations except a temporary increase in choline to ethanolamine containing phospholipids. The function of vascular fragments in total brain, in particular alkaline phosphatase, glutamate transpeptidase and uptake of deoxymethylglucose was found not to be greatly modified after prenatal exposure. From these and the previously reported data it is concluded that the late changes in brain after prenatal irradiation involve mainly the neurons but less the vascular system and myelination.
Bibliographic Reference: SYMPOSIUM "RADIATION RISKS TO THE DEVELOPING NERVOUS SYSTEM", NEUHERBERG (GERMANY), JUNE 18-20, 1985 WRITE TO CEC LUXEMBOURG, DG XIII/A2, POB 1907 MENTIONING PAPER E 32326 ORA
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Record Number: 1989124048600 / Last updated on: 1987-01-01
Available languages: en