CRITICAL EVALUATION OF NORMAL LEVELS OF MAJOR AND TRACE ELEMENTS IN HUMAN LUNG TISSUE
Lungs constitute an important entry into the body for airborne trace metals. Research over the past decades on the trace element composition of human lung tissue has produced an impressive number of data, scattered all through the medical and analytical chemistry literature. A critical review of the published values may be a useful document in establishing baseline concentrations for future biological monitoring with epidemiological and occupational objectives. Unfortunately, a survey of the available information on the concentrations present in lung tissues discloses serious inconsistencies, implying that sampling errors, wrong sample handling, poor analyses and sometimes poor choice of techniques are at stake. Only part of the questionable discrepancies can eventually be explained by the impact of personal backgrounds. The objective of this report is a critical review of the published data of trace metals in human lung suggesting indicative baseline data which are useful for toxicological assessment studies and indicating some research priorities to improve the establishment of trace metal reference levels in human lung from subjects living in the different EEC countries.
Bibliographic Reference: EUR 10440 EN (1986) FS, 141 P., BFR 350, EUROFFICE, LUXEMBOURG, POB 1003
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Record Number: 1989124123900 / Last updated on: 1987-01-01
Available languages: en