Community Research and Development Information Service - CORDIS

Abstract

An N-ecotropic murine leukemia virus (OA MuLV), originally isolated from spontaneous osteomas of strain 101 mice, was molecularly cloned. The virus induces osteomas, osteopetrosis, and malignant lymphomas in NMRI mice. The cloned virus was analyzed by heteroduplex analysis, restriction enzyme mapping, and oligonucleotide mapping. The data show a very close relationship to the endogenous Akv prototype virus with some differences in the gag and the env region. The nucleotide sequence of the U-3 region of OA MuLV LTR revealed a structure within the presumable enhancer region very similar to the U-3 sequences of the FBJ murine sarcoma virus and its associated helper virus. The significance of these specific structures for the oncogenicity of the virus and the development of the typical disease pattern is discussed.

Additional information

Authors: LEIB MOESCH C, MEDIZINISCHE POLIKLINIK DER UNIVERSITAET MUENCHEN (GERMANY);GESELLSCHAFT FUER STRAHLEN- UND UMWELTFORSCHUNG, NEUHERBERG (GERMANY);UNIVERSITY OF AARHUS (DENMARK);HEHLMANN R, MEDIZINISCHE POLIKLINIK DER UNIVERSITAET MUENCHEN (GERMANY);GESELLSCHAFT FUER STRAHLEN- UND UMWELTFORSCHUNG, NEUHERBERG (GERMANY);UNIVERSITY OF AARHUS (DENMARK);SCHMIDT J, MEDIZINISCHE POLIKLINIK DER UNIVERSITAET MUENCHEN (GERMANY);GESELLSCHAFT FUER STRAHLEN- UND UMWELTFORSCHUNG, NEUHERBERG (GERMANY);UNIVERSITY OF AARHUS (DENMARK);ERFLE V, MEDIZINISCHE POLIKLINIK DER UNIVERSITAET MUENCHEN (GERMANY);GESELLSCHAFT FUER STRAHLEN- UND UMWELTFORSCHUNG, NEUHERBERG (GERMANY);UNIVERSITY OF AARHUS (DENMARK);ETZERODT M, MEDIZINISCHE POLIKLINIK DER UNIVERSITAET MUENCHEN (GERMANY);GESELLSCHAFT FUER STRAHLEN- UND UMWELTFORSCHUNG, NEUHERBERG (GERMANY);UNIVERSITY OF AARHUS (DENMARK);PEDERSEN F S MEDIZINISCHE POLIKLINIK DER UNIVERSITAET MUENCHEN (GERMANY), MEDIZINISCHE POLIKLINIK DER UNIVERSITAET MUENCHEN (GERMANY);GESELLSCHAFT FUER STRAHLEN- UND UMWELTFORSCHUNG, NEUHERBERG (GERMANY);UNIVERSITY OF AARHUS (DENMARK);GESELLSCHAFT FUER STRAHLEN- UND UMWELTFORSCHUNG, NEUHERBERG (GERMANY), MEDIZINISCHE POLIKLINIK DER UNIVERSITAET MUENCHEN (GERMANY);GESELLSCHAFT FUER STRAHLEN- UND UMWELTFORSCHUNG, NEUHERBERG (GERMANY);UNIVERSITY OF AARHUS (DENMARK);UNIVERSITY OF AARHUS (DENMARK), MEDIZINISCHE POLIKLINIK DER UNIVERSITAET MUENCHEN (GERMANY);GESELLSCHAFT FUER STRAHLEN- UND UMWELTFORSCHUNG, NEUHERBERG (GERMANY);UNIVERSITY OF AARHUS (DENMARK)
Bibliographic Reference: VIROLOGY, VOL. 150 (1986), PP. 96-105
Record Number: 1989124135000 / Last updated on: 1987-01-01
Category: PUBLICATION
Available languages: en
Follow us on: RSS Facebook Twitter YouTube Managed by the EU Publications Office Top