THE FREQUENCY OF DOMINANT CATARACT AND RECESSIVE SPECIFIC LOCUS MUTATIONS IN MICE DERIVED FROM 80 OR 160 MG ETHYLNITROSOUREA PER KG BODY WEIGHT TREATED SPERMATOGONIA
A systematic comparison of the frequency of dominant cataract and recessive specific locus mutations in mice has been extended to include results for 80 and 160 mg ethylnitrosourea per kg body weight spermatogonial treatment. The frequency of confirmed dominant cataract mutations in the historical control, 80 and 160 mg/kg ethylnitrosourea treatment groups was 1/22 594, 8/5090 and 14/6435, respectively. The frequency of recessive specific locus mutations in the same dose groups was, respectively, 19/227 805, 20/13 274 and 35/8658. These present results confirm previous results, which indicate that ethylnitrosourea is effective in inducing both recessive specific locus and dominant cataract mutations although the per locus mutation rate to recessive alleles was observed to be approximately 6 times greater than the per locus mutation rate to dominant alleles.
Bibliographic Reference: MUTATION RESEARCH, VOL. 162 (1986), PP. 69-80
Record Number: 1989125053900 / Last updated on: 1987-11-01
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