ENZYME ACTIVITY MUTATIONS DETECTED IN MICE AFTER PATERNAL FRACTIONATED IRRADIATION
(101/E1 X C3H/E1)F-1-hybrid male mice were exposed in a 24 h fractionation interval to either 3.0 + 3.0-Gy or 5.1 + 5.1-Gy X-irradiation, and mated to untreated Test stock females. The offspring were examined for mutations at 7 recessive specific loci and for activity alterations of erythrocyte enzymes controlled presumably by 12 loci. No enzyme - activity mutant was found in 3610 F-1-offspring of the control group. In the experimental groups, no mutant was detected in 533 (3.0 + 3.0 Gy) and 173 (5.1 + 5.1 Gy) offspring from postspermatogonial germ cells treated. After treatment of spermatogonia, 1 mutant in 3388 F-1-offspring of the 3.0 + 3.0-Gy group, and 5 mutants in 3187 F-1 offspring of the 5.1 + 5.1-Gy group were found. The mutants were all genetically confirmed. The frequency (expressed as mutants/locus/gamete) of enzyme - activity mutations is 2 (5.1 + 5.1-Gy group) to 10 (3.0 + 3.0-Gy group) times lower than the frequency of recessive specific locus mutations.
Bibliographic Reference: MUTATION RESEARCH, VOL. 160 (1986), PP. 243-248
Record Number: 1989125073900 / Last updated on: 1987-12-01
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