Community Research and Development Information Service - CORDIS

Abstract

Toxicological research directed towards establishing nd dose-response relationships for trace metals demands specific analytical procedures that can differentiate between the various chemical forms : (1) to identify specific trace metal compounds involved in the human exposure (chemical speciation); (ii) to identify the biochemical nature of trace metals in their metabolic patterns in the body (biochemical speciation). Unfortunately, very little is known about the trace metal species to which man is actually exposed or about the biotransformations occurring in the body. This course concerns analytical problems and applications related to metallobiochemistry of trace metal pollution research at the JRC-Ispra with particular emphasis to the aspect of tyrace metal specification. Selected publications are enclosed as typical examples of such a research. They show: the production of radiotracers with high specific radioactivity and their use in the preparation of current environmental levels of trace metal species; the use of the neutron activation analysis (NAA) and radiochemical techniques in metal speciation in liquid and solid environmental and biochemical samples; the in vivo and in vitro applications on the interactions of trace metals with biological systems and biotransformations which include the combined use of nuclear and radiochemical with biochemical techniques of cellular fractionation.

Additional information

Authors: SABBIONI E JRC ISPRA ESTAB. (ITALY), JRC ISPRA ESTAB. (ITALY)
Bibliographic Reference: RELIABILITY IN ENVIRONMENTAL TRACE ANALYSIS, ISPRA (ITALY), MAY 4-8, 1987 WRITE TO CEC LUXEMBOURG, DG XIII/A2, POB 1907 MENTIONING PAPER E 33511 ORA
Availability: Can be ordered online
Record Number: 1989126019801 / Last updated on: 1989-01-01
Category: PUBLICATION
Available languages: en