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Abstract

The cytotoxicity induced by potassium chromate was studied by BALBE-3T3 cells applying a clonal growth assay. The amount of chromium incorporated by the cells increased linearly during the first 24 hrs reaching 8% of the total dose dish at 48 hrs and plateaued thereafter with no further accumulation. At the beginning of the exposure of the cells to chromate, 70% of the Cr present in the medium was extractable as Cr and 72 hrs later only 10% of the initial dose was still extractable as hexavalent chromium. Potassium chromate was found positive in the morphological transformation assay with the BALBE-3T3 C1 A3a-1-1 cell line in the mu range. Induction of cytotoxicity and neoplastic transformation by arsenic salts were also investigated. As was found to have higher toxicity than As and both sodium arsenite and arsenate were positive in the morphological transformation assay.

Additional information

Authors: BERTOLERO F, JRC ISPRA ESTAB. (ITALY);SABBIONI E, JRC ISPRA ESTAB. (ITALY);EDEL J, JRC ISPRA ESTAB. (ITALY);PIETRA R JRC ISPRA ESTAB. (ITALY), JRC ISPRA ESTAB. (ITALY)
Bibliographic Reference: INTERNATIONAL SYMPOSIUM ON BIOCHEMICAL AND CELLULAR INDICES OF HUMAN TOXICITY IN OCCUPATIONAL AND ENVIRONMENTAL MEDICINE, MILANO (ITALY), MAY 19-22, 1986 WRITE TO CEC LUXEMBOURG, DG XIII/A2, POB 1907 MENTIONING PAPER E 32651 ORA
Availability: Can be ordered online
Record Number: 1989126023101 / Last updated on: 1989-01-01
Category: PUBLICATION
Available languages: en
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