MONITORAGGIO BIOLOGICO DELLA ESPOSIZIONE PROFESSIONALE E AMBIENTALE AL PENTACLOROFENOLO
Pentachlorophenol (PCP) is an extremely versatile biocide which is used for preservation in industry and domestic applications. Scope of the present study was to evaluate human exposure to PCP and to identify appropriate biological indicators of exposure. Therefore PCP concentrations in the urine of tannery workers and of professionally not exposed people and their daily variations have been determined. In addition PCP concentrations in different environmental matrices have been determined. Mean concentrations of PCP in the urine of unexposed Italians was 8.6 /-ug/l (from 4.9 to 12.5). People living in homes where PCP had been applied - even many years ago - for indoor wood preservation showed increased PCP concentrations ranging from 22 to 109 /-ug/l. PCP concentrations in the urine of tannery workers varied as a function of their activity with typical values in the range 200-500 /-ug/l and peak values of 2000 /-ug/l. Kinetics of the urinary PCP elimination were not constant during a day but showed significant peaks of the excretion in the morning urine. It can be concluded that the PCP concentration in the morning urine is the indicator of choice for the biological monitoring of human exposure to PCP.
Bibliographic Reference: 48ESIMO CONGRESSO NAZIONALE DELLA SOCIETA ITALIANA DI MEDICINA DEL LAVORO E IGIENE INDUSTRIALE, PAVIA (ITALY), SEPT. 18-21, 1985 WRITE TO CEC LUXEMBOURG, DG XIII/A2, POB 1907 MENTIONING PAPER I 32409 ORA
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Record Number: 1989126035601 / Last updated on: 1989-01-01
Available languages: it