EFFECTS OF LOW DIETARY INTAKE OF METHIONINE, CHOLINE OR PROTEINS ON THE BIOTRANSFORMATION OF ARSENITE IN THE RABBIT
The effects of 6 weeks' feeding with diets low in methionine, choline, or proteins on the biotransformation and retention of 76-As-labelled arsenite (0.4 mg As/kg bw) in rabbits have been studied. All test diets caused a significant decrease in the urinary excretion of dimethyl(7u6As)-arsinic acid, the main metabolite of inorganic arsenic. This gave rise to an increased retention of arsenic in the tissues, especially liver and lung. The test diets also caused a specific increase of the arsenic concentration in liver microsomes. The results indicate that subjects with a poor nutritional status have a lower capacity of methylating and thereby detoxifying inorganic arsenic.
Bibliographic Reference: TOXICOLOGY LETTERS, VOL. 37 (1987), PP. 41-46
Record Number: 1989126054700 / Last updated on: 1989-03-01
Available languages: en