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Abstract

ASSOCIATED WITH TECHNICAL ADVANCES OF OUR CIVILIZATION IS A RADIATION- AND CHEMICALLY- INDUCED INCREASE IN THE GERM CELL MUTATION RATE IN MAN. THE DIFFERENT METHODS TO ESTIMATE THE RADIATION-INDUCED GENETIC RISK ARE DISCUSSED. THE ACCURACY OF THE PREDICTED RESULTS ARE EVALUATED BY A COMPARISON WITH THE OBSERVED INCIDENCE OF DOMINANT MUTATIONS IN OFFSPRING BORN TO RADIATION EXPOSED SURVIVORS OF THE HIROSHIMA AND NAGASAKI ATOMIC BOMBINGS. THESE METHODS ARE USED TO PREDICT THE GENETIC DAMAGE FROM THE FALLOUT OF THE REACTOR ACCIDENT AT CHERNOBYL. FOR THE EXPOSURE DOSE THE UPPER LIMITS OF THE MEAN EFFECTIVE LIFE TIME EQUIVALENT DOSE FROM THE FALLOUT VALUES IN THE MUNICH REGION ARE USED. ACCORDING TO THE DIRECT METHOD FOR THE RISK ESTIMATION FOR EACH 100-500 SPONTANEOUS DOMINANT MUTATIONS 1 RADIATION-INDUCED MUTATION IS EXPECTED IN THE FIRST GENERATION. WITH THE INDIRECT METHOD THERE IS AN ESTIMATED RATIO OF 100 DOMINANT SPONTANEOUS MUTATIONS TO 1 RADIATION-INDUCED DOMINANT MUTATION. THE POSSIBILITIES AND THE LIMITATIONS OF THE DIFFERENT METHODS TO ESTIMATE THE GENETIC RISK ARE DISCUSSED. THE DISCREPANCY BETWEEN THE HIGH SAFETY STANDARDS FOR RADIATION PROTECTION AND THE LOW LEVEL OF KNOWLEDGE FOR THE TOXICOLOGICAL EVALUATION OF CHEMICAL MUTAGENS IS EMPHASIZED.

Additional information

Authors: EHLING U H, INSTITUT FUER SAUGETIERGENETIK GESELLSCHAFT FUER STRAHLEN UND UMWELTFORSCHUNG, NEUHERBERG, D;FAVOR J INSTITUT FUER SAUGETIERGENETIK GESELLSCHAFT FUER STRAHLEN UND UMWELTFORSCHUNG, NEUHERBERG, D, INSTITUT FUER SAUGETIERGENETIK GESELLSCHAFT FUER STRAHLEN UND UMWELTFORSCHUNG, NEUHERBERG, D
Bibliographic Reference: PAPER PRESENTED: DIE WIRKUNG NIEDRIGER STRAHLEN DOSEN AUF DEN MENSCHEN, MUNSTER/D, FEB. 26-27, 1988, AVAILABILITY: CEC-LUXEMBOURG, DG XIII/A2, BP 1907, MENTIONING PAPER ORA 34229 D
Availability: Can be ordered online
Record Number: 1989126211900 / Last updated on: 1989-04-01
Category: PUBLICATION
Available languages: de