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Abstract

THE PUBLICATION IS BASED ON MATERIAL PRESENTED AT AN INTERNATIONAL WORKSHOP HELD IN LUXEMBOURG IN 1987. PART I COVERS THE CONSENSUS REPORT (INCLUDING RECOMMENDATIONS) WHICH AROSE FROM THE DISCUSSIONS ON PART II, THE TECHNICAL REPORT. THE CHALLENGE FACING SCIENTISTS AND REGULATORY AGENCIES IS TO DEVISE AND APPLY CONVENIENT METHODS FOR ASSESSING THE TOXICITY OF AND MEASURING THE EXPOSURE TO GENOTOXIC CHEMICALS. THESE SUBSTANCES ARE OF SPECIAL CONCERN BECAUSE EXPOSURE MAY RESULT IN THE DEVELOPMENT OF CANCER. NINE TYPES OF METHODS ARE CURRENTLY AVAILABLE OR UNDER DEVELOPMENT. THEIR USEFULNESS FOR EXPOSURE AND HEALTH RISK ASSESSMENT IS DISCUSSED IN DETAIL. THEY COVER: 1) METHODS MEASURING THE CHEMICAL OR ITS METABOLITE IN BIOLOGICAL MEDIA, 2) DETERMINATION OF MUTAGENIC ACTIVITY IN BIOLOGICAL MEDIA, 3) CYTOGENIC OBSERVATIONS ON HUMAN SOMATIC CELLS, 4) DETECTION OF GENE MUTATIONS IN SOMATIC CELLS, 5) MOLECULAR DOSIMETRY (DNA AND PROTEIN ADDUCTS), 6) DETERMINATION OF 'TUMOUR MARKERS', 7) DETERMINATION OF DNA REPAIR, 8) SPERM ASSAYS, AND 9) DETERMINATION OF NUCLEIC ACID DAMAGE BY PRODUCTS. NONE OF THESE METHODS IS ABLE TO ASSESS THE HEALTH RISK AT THE INDIVIDUAL LEVEL, BUT THOSE WHICH ARE ABLE TO IDENTIFY GROUPS WHO ARE POTENTIALLY AT RISK ARE INDICATED.

Additional information

Authors: AITIO A, CENTRE INTERNATIONAL DE RECHERCHE SUR LE CANCER, LYON, F;WORLD HEALTH ORGANISATION, IPCS, NIEHS, USA;CEC-LUXEMBOURG;UCL, BRUSSELS;CLINICA DEL LAVORO, LUIGI DEVOTO, MILANO, I;WORLD HEALTH ORGANISATION, COPENHAGEN;UNIV. OF STOCKHOLM;BECKING G, CENTRE INTERNATIONAL DE RECHERCHE SUR LE CANCER, LYON, F;WORLD HEALTH ORGANISATION, IPCS, NIEHS, USA;CEC-LUXEMBOURG;UCL, BRUSSELS;CLINICA DEL LAVORO, LUIGI DEVOTO, MILANO, I;WORLD HEALTH ORGANISATION, COPENHAGEN;UNIV. OF STOCKHOLM;BERLIN A, CENTRE INTERNATIONAL DE RECHERCHE SUR LE CANCER, LYON, F;WORLD HEALTH ORGANISATION, IPCS, NIEHS, USA;CEC-LUXEMBOURG;UCL, BRUSSELS;CLINICA DEL LAVORO, LUIGI DEVOTO, MILANO, I;WORLD HEALTH ORGANISATION, COPENHAGEN;UNIV. OF STOCKHOLM;BERNARD A, CENTRE INTERNATIONAL DE RECHERCHE SUR LE CANCER, LYON, F;WORLD HEALTH ORGANISATION, IPCS, NIEHS, USA;CEC-LUXEMBOURG;UCL, BRUSSELS;CLINICA DEL LAVORO, LUIGI DEVOTO, MILANO, I;WORLD HEALTH ORGANISATION, COPENHAGEN;UNIV. OF STOCKHOLM;FOA V, CENTRE INTERNATIONAL DE RECHERCHE SUR LE CANCER, LYON, F;WORLD HEALTH ORGANISATION, IPCS, NIEHS, USA;CEC-LUXEMBOURG;UCL, BRUSSELS;CLINICA DEL LAVORO, LUIGI DEVOTO, MILANO, I;WORLD HEALTH ORGANISATION, COPENHAGEN;UNIV. OF STOCKHOLM;KELLO D, CENTRE INTERNATIONAL DE RECHERCHE SUR LE CANCER, LYON, F;WORLD HEALTH ORGANISATION, IPCS, NIEHS, USA;CEC-LUXEMBOURG;UCL, BRUSSELS;CLINICA DEL LAVORO, LUIGI DEVOTO, MILANO, I;WORLD HEALTH ORGANISATION, COPENHAGEN;UNIV. OF STOCKHOLM;KRUG E P, CENTRE INTERNATIONAL DE RECHERCHE SUR LE CANCER, LYON, F;WORLD HEALTH ORGANISATION, IPCS, NIEHS, USA;CEC-LUXEMBOURG;UCL, BRUSSELS;CLINICA DEL LAVORO, LUIGI DEVOTO, MILANO, I;WORLD HEALTH ORGANISATION, COPENHAGEN;UNIV. OF STOCKHOLM;LEONARD A, CENTRE INTERNATIONAL DE RECHERCHE SUR LE CANCER, LYON, F;WORLD HEALTH ORGANISATION, IPCS, NIEHS, USA;CEC-LUXEMBOURG;UCL, BRUSSELS;CLINICA DEL LAVORO, LUIGI DEVOTO, MILANO, I;WORLD HEALTH ORGANISATION, COPENHAGEN;UNIV. OF STOCKHOLM;NORDBERG G CENTRE INTERNATIONAL DE RECHERCHE SUR LE CANCER, LYON, F, CENTRE INTERNATIONAL DE RECHERCHE SUR LE CANCER, LYON, F;WORLD HEALTH ORGANISATION, IPCS, NIEHS, USA;CEC-LUXEMBOURG;UCL, BRUSSELS;CLINICA DEL LAVORO, LUIGI DEVOTO, MILANO, I;WORLD HEALTH ORGANISATION, COPENHAGEN;UNIV. OF STOCKHOLM;WORLD HEALTH ORGANISATION, IPCS, NIEHS, USA, CENTRE INTERNATIONAL DE RECHERCHE SUR LE CANCER, LYON, F;WORLD HEALTH ORGANISATION, IPCS, NIEHS, USA;CEC-LUXEMBOURG;UCL, BRUSSELS;CLINICA DEL LAVORO, LUIGI DEVOTO, MILANO, I;WORLD HEALTH ORGANISATION, COPENHAGEN;UNIV. OF STOCKHOLM;CEC-LUXEMBOURG, CENTRE INTERNATIONAL DE RECHERCHE SUR LE CANCER, LYON, F;WORLD HEALTH ORGANISATION, IPCS, NIEHS, USA;CEC-LUXEMBOURG;UCL, BRUSSELS;CLINICA DEL LAVORO, LUIGI DEVOTO, MILANO, I;WORLD HEALTH ORGANISATION, COPENHAGEN;UNIV. OF STOCKHOLM;UCL, BRUSSELS, CENTRE INTERNATIONAL DE RECHERCHE SUR LE CANCER, LYON, F;WORLD HEALTH ORGANISATION, IPCS, NIEHS, USA;CEC-LUXEMBOURG;UCL, BRUSSELS;CLINICA DEL LAVORO, LUIGI DEVOTO, MILANO, I;WORLD HEALTH ORGANISATION, COPENHAGEN;UNIV. OF STOCKHOLM;CLINICA DEL LAVORO, LUIGI DEVOTO, MILANO, I, CENTRE INTERNATIONAL DE RECHERCHE SUR LE CANCER, LYON, F;WORLD HEALTH ORGANISATION, IPCS, NIEHS, USA;CEC-LUXEMBOURG;UCL, BRUSSELS;CLINICA DEL LAVORO, LUIGI DEVOTO, MILANO, I;WORLD HEALTH ORGANISATION, COPENHAGEN;UNIV. OF STOCKHOLM
Bibliographic Reference: EUR 11642 EN (1988) FS, PP 191, ECU 15.00, AVAILABILTY: EUROFFICE, LUXEMBOURG, BP 1003, GDL
Availability: Can be ordered online
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