CRITICAL REVIEW OF ANIMAL CARCINOGENESIS BY NICKEL AND ITS INORGANIC COMPOUNDSFunded under: FP1-RADPROT 6C
Nickel animal carcinogenic biassays relative to nine inorganic nickel substances (nickel metal, nickel oxide(s), nickel subsulphide, nickel sulphide(s), nickel carbonate(s), nickel hydroxide(s), nickel sulphate(s), nickel chloride and nickel carbonyl) and to nickel mixtures (mixtures of nickel substances, complex nickel substances, nickel alloys) are reviewed. Critical evaluation of literature data on carcinogenicity has been performed by reference to EC guidelines of good laboratory practice (part 1). Experimental results are reported in data sheets (part 2). There are few experiments on routes relevant for human risk assessment. No carcinogenic effects have been demonstrated following oral administration for the nickel inorganic compounds under study; results on the inhalation route are inconclusive except for nickel oxide(s) for which they could be negative, but nickel subsulphide appears highly carcinogenic in one experiment. For routes which are of lesser or no relevance for human risk assessment, some results are clearly positive, but methodologically acceptable negative studies are in limited number. Whatever the route of administration, no primary malignant tumours seemed to occur in remote organs, In most cases, carcinogenic effects have been demonstrated for only one species.
Bibliographic Reference: EUR 12456 EN (1989) PART 1: 80 PP., FS, ECU 7.50, PART 2: 283 PP., FS, ECU 22.50 AVAILABLE FROM THE OFFICE FOR OFFICIAL PUBLICATIONS OF THE EUROPEAN COMMUNITIES, L-2985 LUXEMBOURG
Availability: Can be ordered online
Record Number: 1989128015900 / Last updated on: 1990-11-09
Available languages: en