METALLOBIOCHEMISTRY OF CURRENT ENVIRONMENTAL LEVELS OF TRACE METALS - A NEW METHOD OF CYCLOTRON PRODUCTION OF 48V FOR TOXICOLOGICAL STUDIES
No-carrier-added 48V at 37 Mbq (mCi) levels was produced at the JRC- Ispra cyclotron by (alpha,n) reactions on a scandium target and used to label environmental and physiological levels of vanadium for metallobiochemical investigations. The radiochemical separation of 48V from Sc is very simple and rapid and involves a single chromatographic step after fast dissolution of the bombarded target. The yield of the separation and the radioisotopic purity of the separated 48V are nearly 100%. A summary of the main results concerning different metabolic investigations on rats including absorption, retention, transfer of 48V from mothers to newborns, and binding with enzymes as well as uptake by the cell culture system is reported.
Bibliographic Reference: ARTICLE: JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY, VOL. 134 (1989) NO.1, PP. 199-208
Record Number: 1989128074300 / Last updated on: 1990-10-01
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