Community Research and Development Information Service - CORDIS


This book presents a correlation of the technical and chemical properties of polymers with their haemocompatibility. The cellular responses in the blood upon contact with biomaterials and the dynamic adsorption of plasma proteins on the surface of polymers are studied. The resulting contact activation is described together with the methods for its measurement. The principles of polymer chemistry are related to the mechanical, physiochemical and other characteristics of biomaterials. The degradation of implanted polymers, especially elastomers, is described. Surface-grafting techniques on polymers to render them haemocompatible are reviewed, methods for the measurement of the effects being included. An overview is given of the clinical activation of the complement system, the immune system and the coagulation system during extracorporeal perfusion through oxygenator and dialyser. The requirements for different methods of sterilisation, the practical implementations and limitations with the risks for the material and for chemical interaction of surface grafted compounds are outlined. A small number of abstracts are included; these stem mainly from research with biomaterials within the European Community Concerted Action EUROXY.

Additional information

Authors: DAWIDS S (EDITOR), Institute of Engineering Design, Technical University of Denmark, Lyngby (DK)
Bibliographic Reference: EUR 12341 EN (1989) 410 pp.
Availability: Kluwer Academic Publishers Group, P.O. Box 322, 3300 AH Dordrecht (NL)
ISBN: ISBN 0-7923-0491-8
Record Number: 199010069 / Last updated on: 1994-12-01
Original language: en
Available languages: en