Community Research and Development Information Service - CORDIS


The document is the consensus report resulting from an international workshop held in Luxembourg in 1987, which concerned indicators in human biological materials for assessing exposure to and/or biological effects of genotoxic chemicals. There are nine major methods presently in use for assessing exposure to both known and unknown genotoxic chemicals. These include measuring the chemical or its metabolites, determination of mutagenic activity, cytogenetic observations, detection of gene mutations and molecular dosimetry (protein and DNA adducts). Those of particular relevance are recommended.

Additional information

Authors: AITIO A, Centre International de Recherche sur le Cancer, Lyon (FR);BECKING G, World Health Organisation, I.P.C.S., Niehs (US);BERLIN A, CEC Luxembourg (LU);BERNARD A, Université Catholique de Louvain, Bruxelles (BE);FOA V, Institute of Occupational Health, Clinica del Lavoro Luigi Devoto, Milano (IT);KELLO D, World Health Organisation, Copenhagen (DK);KRUG E, Square de Port Royal 7, Paris (FR);LEONARD A, Université Catholique de Louvain, Bruxelles (BE);NORDBERG G, University of Umea (SE)
Bibliographic Reference: EUR 11659 DE,EN,FR (1988) 37 pp., FS, ECU 5
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