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Abstract

The conference opened with a consideration of the molecular mechanisms involved in polymorphic drug metabolism and how this might be applied not only to the identification of poor metabolisers, but also of heterozygous individuals. In addition, the application of ezymatic studies to identifying polymorphic substrates and also important drug-drug interactions were discussed. The choice of method for establishing that the metabolism of a drug is polymorphic and for classifying subjects as extensive or poor metabolisers was considered in detail. This was followed by a session on the balance between genetic and non-genetic factors in the variability of drug handling amongst individuals. The direct clinical implications of polymorphic drug metabolism were considered, together with its importance in the development of new drugs. The mechanisms of certain well established polymorphisms, other than oxidative reactions, were presented and the question of inter-ethnic differences in genetic polymorphisms was discussed.

Additional information

Authors: ALVAN G, CEC Bruxelles (BE);BALANT L P, CEC Bruxelles (BE);BECHTEL P R, CEC Bruxelles (BE);BOOBIS A R, CEC Bruxelles (BE);GRAM L F, CEC Bruxelles (BE);PITHAN K (EDITORS), CEC Bruxelles (BE)
Bibliographic Reference: EUR 12379 EN (1990) 207 pp., FS, ECU 20
Availability: (2)
Record Number: 199010204 / Last updated on: 1994-12-01
Category: PUBLICATION
Original language: en
Available languages: en