Neoplastic transformation of C3H10T1/2 cells following single or fractional doses of fission spectrum neutrons and X-rays
The enhanced transforming effect of low dose-rate or fractional doses of high LET radiation compared to high dose-rate or acute exposure, has recently raised considerable interest. In this study C3H10T1/2 cells are used to determine survival and transformation frequencies after exposure to fission spectrum neutrons (average energy of 0.4 MeV, in terms of kerma) given in single doses or in five fractions delivered at 24 hour intervals, and, for comparison, after exposure to X-rays of 250 kVp (HVL=1.5 mmCu) at high dose-rate. The radiation doses studied were 0.1, 0.25, 0.50, 1 and 1.5 Gy for neutrons, and 2, 4, 6, 8 and 10 Gy for X-rays. Cells were irradiated in the exponential phase of growth. Results confirmed that fission spectrum neutrons are more effective than X-rays, both for cell inactivation and for cell transformation. In addition there was no sparing of survival due to neutron dose fractionation. In terms of transformation frequency, the experimental results showed no substantial difference between cells irradiated by single or fractionated doses of neutrons.
Bibliographic Reference: Paper presented: 38th Meeting of the Radiation Research Society, New Orleans (US), April 7-12, 1990
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Record Number: 199011022 / Last updated on: 1994-12-01
Original language: en
Available languages: en