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Cardiovascular diseases are the biggest cause of death in European countries with enormous health and economic consequences. Conventional risk factors such as hyperlipidaemia, hypertension and cigarette smoking explain most but not all of this cardiovascular epidemic. Homocystinuria is an inborn error of metabolism, the heterozygous state for which has recently been implicated as a new factor for cardiovascular disease. Up to 30% of subjects with premature vascular disease may be heterozygous for this condition. The general objectives of this workshop were: (1) to standardise diagnostic techniques in the detection of heterozygous homocystinuria; (2) to establish the prevalence of heterozygous homocystinuria in subjects with vascular disease in different European countries; (3) to establish possible interaction between heterozygous homocystinuria and conventional risk factors for vascular disease; (4) to stimulate new diagnostic methods through the gene probe technique which could become the basis of a simple economic screening programme.

Additional information

Authors: ROBINSON K (EDITOR), The Adelaide Hospital, Dublin (IE)
Bibliographic Reference: EUR 12834 EN (1990) 141 pp., FS, ECU 12.5
Availability: (2)
ISBN: ISBN 92-826-1524-3
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