Vanadium transport across placenta and milk of rats to the fetus and newborn
The transport of vanadium across placenta and milk in rats was studied by i-V injection of low doses of 48V-labelled pentavanadate to pregnant and nursing rats. Significant concentrations of vanadium were found in the liver, intestines and kidneys of the foetuses, showing that vanadium can pass the placental barrier and be metabolised in the foetus. Vanadium in milk may be transported in the form of a biocomplex with lactoferrin, since at 12 d after injection, the 48V in the rat milk was mainly found in fractions corresponding to proteins. In weanling rats, 7 d postlactation and 18 d after administration of vanadium to the mother, only very small amounts of 48V were still present in the organs. Excretion studies on weanling rats for 7 d showed that vanadium is rapidly released mainly via faeces when earlier taken up by the milk of i-V injected mothers and had the same elimination pattern as the milk, which lost about 80% of its vanadium concentration after 12 d.
Bibliographic Reference: Article: Biological Trace Element Research, Vol. 22 (1989) pp. 265-275
Record Number: 199011425 / Last updated on: 1994-12-02
Original language: en
Available languages: en