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Abstract

Cytotoxicity, morphological transformation and cellular retention were studied in BALB/3T3 Cl A 31-1-1 cells for vanadium(V) and vanadium(IV). A morphological transformation focus assay showed transforming activity for vanadium(V) while vanadium(IV) did not transform in the cells. Cytotoxicity was higher for vanadium(V) than for vanadium(IV). The cellular retention of both vanadate and vanadyl compounds at 24, 48 and 72 h incubation was similar. At concentrations lower than 1.0 E-6 M vanadate, the retention was linear with the dose, while at higher exposures the vanadium taken up by the cells levelled off or decreased slightly.

Additional information

Authors: SABBIONI E, JRC Ispra (IT);POZZI G, JRC Ispra (IT);PINTAR A, University of Milan, Department of Inorganic and Metallorganic Chemistry, Milano (IT);CASELLA L, University of Milan, Department of Inorganic and Metallorganic Chemistry, Milano (IT);GARATTINI S, Istituto di Ricerche Farmacologiche, Milano (IT)
Bibliographic Reference: Article: Carcinogenesis, Vol. 12 (1991) No. 1, pp. 47-52
Record Number: 199110527 / Last updated on: 1994-12-02
Category: PUBLICATION
Original language: en
Available languages: en