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Micellar electrokinetic capillary chromatography (MECC) was developed and refined for the analysis of major and modified nucleobases, nucleosides and nucleotides. The composition of buffering systems, electrophoretic conditions and dimensions of capillars were investigated in order to obtain best performances. Particular emphasis was placed on the identification of physiological constituents in nucleic acids and their chemically modified analogues. "In vitro" studies on calf thymus DNA exposed to genotoxic agents indicate that adducted bases and nucleotides can be identified by MECC.

Additional information

Authors: LECOQ A F, JRC Ispra (IT);LEURATTI C, JRC Ispra (IT);MARAFANTE E, JRC Ispra (IT);DI BIASE S, Beckman Analytical, Napoli (IT)
Bibliographic Reference: Paper presented: 13th International Symposium on Capillary Chromatography, Riva del Garda (IT), May 13-16, 1991
Availability: Available from (1) as Paper EN 36061 ORA
Record Number: 199110858 / Last updated on: 1994-12-02
Original language: en
Available languages: en
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