Community Research and Development Information Service - CORDIS

Abstract

This paper discusses the current status of Neutron Capture Therapy (NCT), with particular emphasis on recent developments within Europe. Renewed interest has been generated in NCT in recent years, mainly due to the development of improved delivery systems for suitable nuclides and due to improvements in neutron beam quality. The most attractive stable radionuclide for NCT is Boron-10. A review of the suitable neutron sources is included, highlighting the development of a facility at the High Flux Reactor in Petten, where a combination of aluminium, sulphur, liquid argon, cadmium and titanium has been chosen as the filter system. An epithermal neutron beam is generated with an average energy of 7-8 keV, a total neutron flux of 2 x 1.0 E9 n/cm2s and a gamma component with a dose rate of 60 cGy per hour. A summary of the development of boron compounds and their specific tumour seeking characteristics is also included, with additional comments on alternative compounds.

Additional information

Authors: DEWIT L, The Netherlands Cancer Institute, Department of Radiotherapy, Amsterdam (NL);MOSS R L, JRC Petten (NL);GABEL D, University of Bremen, Department of Chemistry (DE)
Bibliographic Reference: Article: European Journal of Cancer, Vol. 26 (1990) No. 8, pp. 912-914
Record Number: 199111633 / Last updated on: 1994-12-02
Category: PUBLICATION
Original language: en
Available languages: en