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Abstract

This report describes the work carried out for certification of the catalytic concentration of creatine kinase (ATP : creatine N-phosphotransferase, EC 2.7.3.2, CK), in a lyophilised solution of partially purified CK-BB from human placenta in a bovine serum albumin matrix. The preparation has been shown to be homogeneous, and the loss of activity on storage at -20 C is predicted to be less than 0.5% per annum on the basis of accelerated degradation studies. The catalytic concentration of CK in samples of the reconstituted material is certified to be 5.42 +/- 0.17 micro-kat/l or 325 +/- 10 U/l according to the IFCC recommended method at 30 C.

Additional information

Authors: MATHIEU M, Hôpital Debrousse, Lyon (FR);STEGHENS J P, Hôpital E. Herriot, Lyon (FR);HORDER M, Odense University Hospital (DK);MOSS D W, Hammersmith Hospital, London (GB);COLINET E, CEC Bruxelles (BE);PROFILIS C, CEC Bruxelles (BE)
Bibliographic Reference: EUR 13886 EN (1992) 51 pp., FS, ECU 6.25
Availability: (2)
ISBN: ISBN 92-826-3399-3
Record Number: 199210036 / Last updated on: 1994-12-02
Category: PUBLICATION
Original language: en
Available languages: en