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Abstract

In experimental auto-immune encephalomyelitis, much progress has been made in the understanding of a detailed characterisation of the trimolecular complex by which T-lymphocytes recognise their auto-antigen, myelin basic protein. In human MS research much interest is now also centred on the trimolecular complex of T-cell recognition involving MBP and, more recently, other myelin antigens such as proteolipid protein. The structure of the meeting reflected these developments. Three sections were devoted to the components of the trimolecular complex, namely T-cell receptor, antigenic peptide, and antigen-presenting HLA molecules. Contributions demonstrated that human immune response to myelin basic protein, and possibly other myelin antigens, seems to be much more complex than it is in some animal strains. Clearly, for recognition of MBP, multiple-cell receptors are used, multiple HLA-DR elements serving as antigen-presenting "restriction-elements". Other important topics discussed were: (i) blood brain barrier; (ii) local micro-environment and the role of facultative autochthonous antigen-presenting cells such as astrocytes, endothelial cells and microglia; (iii) soluble inflammatory mediators and cytokines.

Additional information

Authors: HOHLFELD R, Institute for Neurology, European Charcot Foundation for Multiple Sclerosis Research, Nijmegen (NL);HOMMES O R, Institute for Neurology, European Charcot Foundation for Multiple Sclerosis Research, Nijmegen (NL);WEKERLE H, Institute for Neurology, European Charcot Foundation for Multiple Sclerosis Research, Nijmegen (NL)
Bibliographic Reference: EUR 13852 EN (1992) 37 pp., FS, ECU 5
Availability: (2)
ISBN: ISBN 92-826-3359-4
Record Number: 199210320 / Last updated on: 1994-12-02
Category: PUBLICATION
Original language: en
Available languages: en
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