The Petten BNCT facility : I - Phantom dosimetry techniques used in the nuclear and biological characterisation of the epithermal neutron beam and in the healthy tissue tolerance studies on the canine brain, and II - The development towards
The Petten epithermal neutron beam was operated for the first time at full reactor power in June 1991 for a two week period. During this period, valuable beam characterisation and experimental work was performed. The dosimetry work on the free beam, in the phantoms and for the healthy tissue tolerance studies, has shown that standard dosimetry techniques can be used to provide sufficient information to assist in the nuclear and biological characterisation of the beam. The healthy tissue tolerance studies, involving the irradiation of the first two dogs, were performed satisfactorily. Treatment planning schemes, based on three-dimensional MCNP modelling, have shown that fractionation has only an insignificant effect on improving the therapeutic gain, whilst bilateral or multi-portal irradiations are far more significant, especially at the mid-line of the phantom or head. It is estimated that if the beam is operable again at the beginning of 1992, the start of clinical trials on glioma patients at the HFR Petten could begin before the end of 1993.
Bibliographic Reference: Paper presented: International Workshop on Dosimetry and Treatment Planning for NCT, Boston (US), Oct. 30 - Nov. 1, 1991
Availability: Available from (1) as Paper EN 36442 ORA
Record Number: 199210654 / Last updated on: 1994-12-02
Original language: en
Available languages: en