Community Research and Development Information Service - CORDIS

Abstract

The use of radiotracers with high specific activity in research on the health impact of trace metals overcomes many of the analytical difficulties associated with experimentation carried out at metal levels which are typical of the polluted environment. This technique makes it possible to detect and measure ultratrace amounts of metals in biological samples and to follow them into different biochemical compartments, such as subcellular fractions and molecular components. This work shows typical examples of metallotoxicological studies carried out at the JRC Ispra using radioisotopes with high specific radioactivity produced in the nuclear reactor and in the cyclotron. Applications refer to the use of 45Ti, 48V, 64Cu, 95Nb and 106mAg in both in vivo and in vitro studies related to environmental and occupational toxicology research on trace metals.

Additional information

Authors: SABBIONI E, JRC Ispra (IT);PIETRA R, JRC Ispra (IT);FORTANER S, JRC Ispra (IT);BONARDI M, University and INFN, Accelerator and Applied Superconductivity Laboratory, Milano (IT);GROPPI F, University and INFN, Accelerator and Applied Superconductivity Laboratory, Milano (IT);GALLORINI M, CNR, CRAA, Pavia (IT);TARTAGLIA G P, JRC Petten (NL)
Bibliographic Reference: Paper presented: 11. Methods and Applications of Radioanalytical Chemistry - II, Kona, Hawaii (US), April 21-27, 1991
Availability: Available from (1) as Paper EN 36976 ORA
Record Number: 199211005 / Last updated on: 1994-12-02
Category: PUBLICATION
Original language: en
Available languages: en