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In spite of aggressive treatment schemes employing conventional radiation therapy and neurosurgery, the prognosis for patients suffering from malignant brain tumours such as Glioblastoma Multiforme is still very poor. Boron neutron capture therapy (BNCT) offers a possibility to improve this situation dramatically. This treatment modality is based on the nuclear reaction that occurs when a stable isotope, 10B, is irradiated with low energy neutrons to yield high LET radiation (alpha particles and 7Li nuclei). By accumulating a 10B containing compound predominantly in the tumour, it is possible to focus the radiation damage caused by the 10B(n, alpha) reaction to tumour tissue. A multinational research programme coordinated by the European Collaboration on BNCT is currently being carried out in order to establish all necessary requirements for the first clinical trials on patients. The starting dose for these trials was determined using the results of a dose escalation study. The most crucial structure in the treatment being the CNS, magnetic resonance imagery (MRI) was used to monitor radiation induced brain damage after BNCT because this does not add additional radiation to the brain, but has proved to be an excellent source of information on its integrity.

Additional information

Authors: SIEFERT A, JRC Petten (NL);MULLER H J, University of Utrecht, Bijvoet Centre for Biomolecular Research (NL);TAMMINGA K S, University of Utrecht, Bijvoet Centre for Biomolecular Research (NL)
Bibliographic Reference: Paper presented: 11th Annual Meeting of the Society of Magnetic Resonance in Medicine, Berlin (DE), August 9-14, 1992
Availability: Available from (1) as Paper EN 36929 ORA
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