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Previous studies have shown that particles of high T(c) superconducting materials (HTS) are cytotoxic to bovine alveolar macrophages (BAM) in vitro. In order to clarify the single steps of the interaction between the cells and the particles, an analysis of the intracellular dissolution of the particles was performed. An investigation of the influence of phospholipids on the cytotoxicity of the HTS-particles was then carried out, and studies on the release of pro-inflammatory mediators by different HTS were performed. The results strongly suggest that inhaled HTS particles are potentially toxic. In view of their rapid dissolution in biological systems, heavy metal accumulation in liver, kidney and bone might occur.

Additional information

Authors: BAIERL T ET AL., Forschungszentrum Karlsruhe, Institut für Genetik und Toxikologie (DE);THIELE H, JRC Karlsruhe (DE)
Bibliographic Reference: Paper presented: European Aerosol Conference, Oxford (GB), September 6-11, 1992
Availability: Available from (1) as Paper EN 37236 ORA
Record Number: 199211468 / Last updated on: 1994-11-29
Original language: en
Available languages: en