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  • Brain effects observed in the canine healthy tissue tolerance studies for BNCT with borocaptate sodium at the epithermal neutron beam of the HFR, Petten


The paper summarises the results of magnetic resonance imaging (MRI) performed on neutron-beam irradiated Beagle dog brain tissue at different blood B concentrations. The objective was to determine the tolerance of healthy brain tissue to the epithermal neutron beam of the HFR Petten before conducting clinical trials of BNCT with borocaptate sodium (BSH) on patients suffering from malignant brain tumours. No changes were present in the MRIs obtained shortly after irradiation, showing that BNCT with BSH does not cause an acute leakage of the blood-brain barrier at the applied dose levels. It is as yet too soon to assess the possibility of late neurological damage observed using BNCT in earlier experiments.

Additional information

Authors: SIEFERT A, JRC Petten (NL);CASADO J, JRC Petten (NL);MOSS R L, JRC Petten (NL);PHILIPP K, The Netherlands Energy Research Foundation, Petten (NL);HUISKAMP R, The Netherlands Energy Research Foundation, Petten (NL);GAVIN P R, Washington State University, Department of Veterinary Medicine (US);DÜHMKE E, University of Göttingen, Department of Radiotherapy (DE);DUHMKE E, University of Gottingen, Department of Radiotherapy (DE)
Bibliographic Reference: Paper presented: 5th International Symposium on Neutron Capture Therapy for Cancer, Columbus (US), September 13-17, 1992
Availability: Available from (1) as Paper EN 36854 ORA
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