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The paper summarises the results of investigating the effect of irradiating Beagle dog brain tissue at different blood B concentrations with an epithermal neutron beam before clinical trials of BNCT on glioma patients. The basic methodology used in the system is explained and a practical case is presented for one of the healthy tissue tolerance dogs. Doses, both physical and RBE weighted, were produced for pre-treatment planning studies. The principal objective of the work was to develop a computational model capable of evaluating the various dose components at all positions within a target volume from a predetermined neutron and photon source. The results are very promising and agreement with measured activation foils on the dogs or within phantoms is good.

Additional information

Authors: WATKINS P, JRC Petten (NL);MOSS R L, JRC Petten (NL);SIEFERT A, JRC Petten (NL);HUISKAMP R, The Netherlands Energy Research Foundation, Petten (NL);GAVIN P, Washington State University, Veterinary Department (US);KONIJNENBERG M, The Netherlands Cancer Institute, Amsterdam (NL)
Bibliographic Reference: Paper presented: 5th International Symposium on Neutron Capture Therapy for Cancer, Columbus (US), September 13-17, 1992
Availability: Available from (1) as Paper EN 36855 ORA
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