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Experiments investigating late effects of alpha-particle emitters on animals are generally designed, as far as possible, to be relevant to humans living in a contaminated environment. A method for contaminating mice has been developed using a suspension of a thorium salt containing Th-228 injected paratibially (i.e. into the muscle posterior to the tibia, just touching the bone) into young adult mice. Th-228 is then used as a source of Ra-224, the first daughter, which is continuously translocated and deposited in the skeleton. Only a small part of the deposited Th-228 moves away from the site of injection to other parts of the skeleton. This pattern of dual contamination of the skeleton may be a better model for human exposure to environmental plutonium for example than single or even multiple injection of bone surface seeking radionuclides (e.g. Ra-224) into a mouse. Within 9 months a total skeletal dose of about 150 mGy was reached, after injection of 40 Bq of Th-228. The results of an experiment which has been started with this dose, using a greater number of animals, is contrasted to results from earlier experiments performed with single or multiple injections of Ra-224.

Additional information

Authors: MÜLLER W A, GSF-Institut für Pathologie, Neuherberg (DE);MULLER W A, GSF-Institut fur Pathologie, Neuherberg (DE)
Bibliographic Reference: Paper presented: 9th International Congress of Radiation Research, Toronto (CA), July 7-12, 1991
Availability: Text not available
Record Number: 199310639 / Last updated on: 1994-11-29
Original language: en
Available languages: en