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When biomaterials are exposed to blood a rapid sequence of events occurs. Many of these have not been fully elucidated and their role in, for example, the patency of a vascular graft, is unknown. This book contains a collection of selective tests for the evaluation of blood compatible materials. Equipment and materials used in each test are listed and, for most tests, reference results are provided. Guidelines for the selection of animals for such tests are outlined and test methods are described in relation to each of the following: (i) the detection of mechanical properties; (ii) biodegradation detection; (iii) surface analysis; (iv) the detection of protein adsorption on polymers; (v) the activation of haemostasis and other activation systems; (vi) detection of thrombosis, fibrinolysis and emboli formation; (vii) toxicity detection. A separate chapter includes rules for good manufacturing practice and good laboratory practice.

Additional information

Authors: DAWIDS S (EDITOR), Konstruktionsteknik/DTH, Instituttet for Konstruktionsteknik, Danmarks Tekniske Hojskole, Lyngby (DK)
Bibliographic Reference: Report: EN (1993) 684 pp.
Availability: Kluwer Academic Publishers Group, P.O. Box 322, 3300 AH Dordrecht (NL)
ISBN: ISBN 0-7923-2107-3
Record Number: 199310772 / Last updated on: 1994-11-29
Original language: en
Available languages: en
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