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  • Certification of the mass concentration of three stilbenes in bovine urine reference materials by gas chromatographic-mass spectrometric methods : Sources of error and their control


In confirming the presence of residues in various tissue samples, procedures based on gas chromatography-mass spectrometry (GC-MS) are the chosen methods. The accuracy, repeatability and reproducibility of existing and/or new GC-MS procedures can be checked by certified matrix matched reference materials (CRMs). Reference materials provide support for the quality control in reference laboratories and for the quality criteria of residue analysis. However, in arriving at a certified value there are several important objectives such as the elimination of various sources of errors. This paper discusses some analytical errors detected in the certification study on three stilbenes in bovine urine reference materials. The coefficients of variation for the repeatability (within-laboratory), reproducibility (between-laboratory), and for some calibration parameters, are compared with those available from the literature. A link to proficiency schemes for laboratory accreditation and laboratory control purposes is also given.

Additional information

Authors: BOENKE A, CEC Bruxelles (BE)
Bibliographic Reference: Paper presented: International Symposium on Hormone and Veterinary Drug Residue Analysis, Gent (BE), May 19-22, 1992
Availability: Available from (1) as Paper EN 36826 ORA
Record Number: 199310848 / Last updated on: 1994-11-29
Original language: en
Available languages: en