Community Research and Development Information Service - CORDIS


Within the framework of the Community's biotechnology research programmes, groups of contractors were brought together to constitute ELWWs, with a view to facilitating the rapid circulation and exchange of information, data and materials, thereby increasing mobility among research staff. The purpose of this brochure is to illustrate the work of one such ELWW in the field of a new in vitro integrated approach to pharmaco-toxicology and metabolism in cancer chemotherapy. The significance of the research is outlined, together with its aims and specific objectives, and progress made in the following areas of research is presented: (i) culture of cancer cells of human origin; (ii) the development of drug-resistant variants of human cancer cells; (iii) reliable assays for measuring the efficacy of drugs against human cancer cells grown in culture; (iv) the isolation, cryopreservation and culture of human hepatocytes; (v) the development of an organ slicing technique; (vi) evaluation of drug transport and metabolism; (vii) establishment of an in vitro hepatotoxicity screening protocol.

Additional information

Authors: KLEPSCH A, CEC Bruxelles (BE)
Bibliographic Reference: Report: EN (1990) 16 pp.
Availability: Available from the BAP Programme Office, CEC, DG XII, 200 rue de la Loi, B-1049 Bruxelles (BE)
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