Genetic engineering of foot-and-mouth disease virus antigenFunded under: FP2-BRIDGE
Within the framework of the Community's biotechnology research programmes, groups of contractors were brought together to constitute ELWWs, with a view to facilitating the rapid circulation and exchange of information, data and materials, and increasing mobility among research staff. The purpose of this brochure is to illustrate the work of one such ELWW in the field of the genetic engineering of foot-and-mouth disease virus antigen. Two strategies were followed: (i) the definition of the regions of the virus protein shell, or capsid, that are responsible for eliciting the immune response, and to mimic the so-called B-cell and T-cell epitopes by peptides, either alone or fused for carrier proteins; (ii) the expression and assembly of the entire virus capsid from a cDNA clone. Progress of research is reported in the areas of virion structure; antigenic sites on the virus particle peptide fusions, and expression of empty virus capsids. The complementarity of this research is also discussed.
Bibliographic Reference: Report: EN (1992) 15 pp.
Availability: Available from the BRIDGE Programme Office, CEC, DG XII, 200 rue de la Loi, B-1049 Bruxelles (BE)
Record Number: 199330018 / Last updated on: 1994-11-29
Original language: en
Available languages: en