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This report contains the proceedings of a one-day meeting held in Sorrento in 1991. The first few papers concern the regulators of the transcription of liver specific genes. The genetic determinants that regulate liver transcription are then analysed. The characterisation of several new mutations in the clotting factor IX promoter is described. The structure of the different classes of the lipoproteins particles (VLD, LDL and HDL) and their function in lipid and cholesterol transport is reviewed. The characterisation of signals and proteins involved in the acute phase response and in the effect of the extracellular matrix on liver differentiation is also discussed. Finally, the structure and composition of the extracellular matrix present in liver is reviewed, and future experiments aimed at the analysis of the morphogenetic role of collagen IV and the regulation of extracellular matrix synthesis by cytokines are described.

Additional information

Authors: CEC, CEC Bruxelles (BE)
Bibliographic Reference: Report: EN (1991) 21 pp.
Availability: Available from the BRIDGE Programme Office, CEC, DG XII, 200 rue de la Loi, B-1049 Bruxelles (BE)
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