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The aim of this paper is to provide information on metabolic patterns of Np in the rat at tissue, subcellular and molecular level by means of 239Np alone or in combination with 237Np as carrier. Particular emphasis is placed on the determination of the gastrointestinal absorption of the element. Groups of fed and fasted animals were given 150 mg Np/rat or 1 ng Np/rat orally in order to determine retention, hepatic and renal intracellular distribution as well as the association of the radioelement with hepatic, renal and plasma components. The retention of Np was not dependent on its level of exposure. This conclusion is also supported by similarities in the liver and kidney intracellular distribution. These retention data suggest that only a high mass of the element would influence its gastrointestinal absorption.

Additional information

Authors: EDEL J, JRC Ispra (IT);SABBIONI E, JRC Ispra (IT);MOUSTY F, JRC Ispra (IT);PIETRA R, JRC Ispra (IT)
Bibliographic Reference: Article: Journal of Trace and Microprobe Techniques, Vol. 11 (1993) Nos. 1-3, pp. 179-192
Record Number: 199410016 / Last updated on: 1994-11-28
Original language: en
Available languages: en