Community Research and Development Information Service - CORDIS

Abstract

Trace metal imbalances can occur in uremic subjects with chronic renal failure. These disturbances could be implied in symptoms observed in patients under regular dialysis. In particular, several accidental acute intoxications in dialysis patients, resulting from contamination of the dialysate, have been reported for metals such as Cu, F, Ni and Zn(2). The aim of this paper is to show the influence that high specific radioactivity radiotracers exert on the behaviour of trace metals during the dialysis process, as investigated through an ex vivo dialysis closed system. Applications reported concern: (i) the kinetics of the transfer of trace metals from dialysate to the blood and vice-versa; (ii) the complexation of trace metals in the dialysis bath as a potential means of decreasing trace metal exposure in dialysis patients.

Additional information

Authors: SABBIONI E ET AL., JRC Ispra (IT);BRANCACCIO D ET AL., Ospedale S. Paolo, Renal Unit, Milano (IT);CANAVESE C, Ospedale Maggiore S. Giovanni Battista, Divisione Nefrologia e Dialisi, Torino (IT);INGROSSO G, Ospedale di Circolo, Servizio Trasfusionale e di Immunoematologia, Varese (IT)
Bibliographic Reference: Article: Journal of Trace and Microprobe Techniques, Vol. 11 (1993) Nos. 1-3, pp. 193-215
Record Number: 199410017 / Last updated on: 1994-11-28
Category: PUBLICATION
Original language: en
Available languages: en