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The JRC activity at Ispra on trace metal exposure and health effects aims to provide technical support for implementing regulatory actions in order to prevent potential health risks of exposure to certain trace metals. This paper presents typical results which can be obtained in the context of the metallo-toxicological research by nuclear, radioanalytical and spectrochemical techniques. Applications related to the in vivo work on laboratory animals, in vitro investigations on isolated biological systems, and analytical determinations of trace metals in human tissues are reported. The selected applications cover the following aspects of the research: (i) environmental toxicology (comparative studies on As (arsenic) and V (vanadium) in laboratory animals, interaction of As compounds with enzymes, background levels of trace metals in urine of the general population); (ii) occupational health toxicology (studies related to hard metal exposure); (iii) biomedical research (investigations related to trace metals and renal insufficiency).

Additional information

Authors: SABBIONI E, JRC Ispra (IT);PIETRA R, JRC Ispra (IT);SERRA M A, JRC Ispra (IT);FORTANER S, JRC Ispra (IT);EDEL J, JRC Ispra (IT);MINOIA C, Fondazione Clinica del Lavoro, Industrial Hygiene Laboratory, Pavia (IT)
Bibliographic Reference: Article: Journal of Trace and Microprobe Techniques, Vol. 11 (1993) Nos. 1-3, pp. 217-233
Record Number: 199410018 / Last updated on: 1994-11-28
Original language: en
Available languages: en