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The main aims of this investigation were to identify a peptide segment of CEA, highly characteristic for CEA but of little or no homology to the CEA cross-reacting antigens, sythesise this peptide fragment by gene technology, and characterise the protein chemical and immunological properties of the CEA-specific peptide fragment. A fragment of 77 amino acid residues in domain B3 of the CEA molecule was identified as useful for the work. This report describes the methods used in the investigation, the results of the work and the outlook for the future. It became clear that the original aim to obtain CEA peptide was not desirable for a number of reasons which are outlined.

Additional information

Authors: SCHEIT K H, Max-Planck-Institut für Biophysikalische Chemie, Göttingen (DE);HANES J, Max-Planck-Institut für Biophysikalische Chemie, Göttingen (DE);VON DER KAMMER H, Max-Planck-Institut für Biophysikalische Chemie, Göttingen (DE);HAGENDORFF G, Karl Friederich-Bonhoeffer Institut, Göttingen (DE);MAST W P, SERATEC, Göttingen (DE)
Bibliographic Reference: EUR 14835 EN (1993) 19 pp., MF, ECU 4
Availability: (2)
Record Number: 199410098 / Last updated on: 1994-11-28
Original language: en
Available languages: en
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