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Animal feed materials, free and containing clenbuterol and salbutamol, were prepared. Their homogeneity and stability were checked and found to be sufficient to be used in this extraction study. The objective of the study was to develop an extraction scheme applicable for different beta-agonists in feed. This procedure should be compatible with several clean-up and chromatographic end-methods and lead to acceptable yields and a low number of co-extractives. The influence on the extraction of five possible critical factors was examined by four laboratories via a ruggedness-test approach. A unique set-up allowed the results to be combined in a complete factorial design. From the five factors, the addition of organic solvent is the most important. Interactions between factors were also studied. The best combinations of factors for extraction yield is given.

Additional information

Authors: COURTHEYN D, Rijksontledingslaboratorium Gent (BE);MOERMANS R, Rijksstation voor Nematologie, Centrum voor Biometrie, Merelbeke (BE);BOENKE A, EC Bruxelles (BE)
Bibliographic Reference: EUR 15273 EN (1993) 65 pp., MF, ECU 4
Availability: (2)
Record Number: 199410104 / Last updated on: 1994-11-28
Original language: en
Available languages: en
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