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This paper focuses on programmes to validate alternative test methods which have been carried out over recent years or are still in progress. These test methods have included the use of cytotoxicity data to predict the acute toxicities of chemicals, and the use of in vitro methods to predict eye irritancy, developmental toxicity, hepatotoxicity and neurotoxicity. Recently, the European Research Group for Alternatives in Toxicity Testing (ERGATT) established a multicentre research project, in which tests or test batteries were selected within eight areas including nephrotoxicity, immunotoxicity and biokinetics. The aim of the programme has been to integrate knowledge of the different areas into an overall assessment of a compound's toxicological hazards. Information is also provided on the European Centre for the Validation of Alternative Methods (ECVAM) which was established in 1992.

Additional information

Authors: BLAAUBOER B J, Utrecht University, Research Institute of Toxicology (RITOX) (NL);BALLS M, JRC Ispra (IT)
Bibliographic Reference: Paper presented: World Congress on Alternatives and Animal Use in the Life Sciences, Baltimore (US), November 14-19, 1993
Availability: Available from (1) as Paper EN 38083 ORA
Record Number: 199410189 / Last updated on: 1994-11-28
Original language: en
Available languages: en