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Abstract

Radiochemical neutron activation analysis has been used to determine the concentration of 36 elements in neuromelanin, 22 elements in substantia nigra and 32 elements in putamen. Iron was present in the highest concentration in all analysed samples. Zinc was also found at high levels in three samples, ranging from 16.8 to 1500 ng/mg. Elements such as Zn, Cr, Se, Sr, Co, Sb, Ni, Hg, Ce, Au, Ag, Ta and Sc were present in neuromelanin at much higher concentrations than in substantia nigra and putamen. The findings indicate that substantia nigra and putamen contain metals at higher concentrations than observed in blood. They also show neuromelanin's particular affinity for metals.

Additional information

Authors: ZECCA L, Istituto di Tecnologie Biomediche Avanzate, CNR, Milano (IT);RADICE D, Istituto di Tecnologie Biomediche Avanzate, CNR, Milano (IT);PIETRA R, JRC Ispra (IT);SABBIONI E, JRC Ispra (IT);GOJ C, Università di Milano, Istituto di Medicina Legale (IT);MECACCI C, Università di Milano, Istituto di Medicina Legale (IT)
Bibliographic Reference: Article: Journal of Neurochemistry, Vol. 62 (1993) No. 3, pp. 1097-1101
Record Number: 199410366 / Last updated on: 1994-11-28
Category: PUBLICATION
Original language: en
Available languages: en