Community Research and Development Information Service - CORDIS


This volume provides an introduction to the series on the evaluation of antidotes and reviews three antidotes: (i) naloxone, a specific opioid antagonist used in the treatment of opiate poisoning; (ii) flumazenil, used to reverse the sedative, anti-convulsant and muscle-relaxant effects of benzodiazapines; (iii) dantrolene sodium, used in the treatment of malignant hyperpyrexia and hyperthermia, neuroleptic malignant syndrome and hypercatabolic syndrome. Information is given on the physico-chemical properties of the antidotes, analytical methods used and studies (animal, volunteer and clinical) conducted.

Additional information

Authors: MEREDITH T J, Department of Health, London (GB);JACOBSEN D, Ulleval University Hospital, Oslo (NO);HAINES J A, IPCS, World Health Organisation, Genève (CH);BERGER J-C (EDITORS), European Commission, Luxembourg (LU)
Bibliographic Reference: EUR 14797 EN (1993) 98 pp.
Availability: Press Syndicate of the University of Cambridge, The Pitt Building, Trumpington Street, Cambridge CB2 1RP (GB)
ISBN: ISBN 0-521-45459-X
Record Number: 199410395 / Last updated on: 1994-11-28
Original language: en
Available languages: en