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Abstract

The mutagenic activity of 7,12-dimethylbenz[a]anthracene in epithelial liver cells (CHEL) in culture was unaffected by the enhancement of intracellular cAMP induced to different extents and with different mechanisms by forskolin and 3-isobutyl-1-methylxanthine. However, the latter compound exerted antimutagenic effects (greater than 60 %), which may be tentatively ascribed to inhibition of the inducible monooxygenase isoforms(s) responsible for the specific biotransformation of 7,12-dimethylbenz[a]anthracene to highly mutagenic metabolites in CHEL cells.

Additional information

Authors: BERTACCA A, CNR, Institute of Mutagenesis and Differentiation, Pisa (IT);CINI M, CNR, Institute of Mutagenesis and Differentiation, Pisa (IT);SBRANA M, CNR, Institute of Mutagenesis and Differentiation, Pisa (IT);TURCHI G, CNR, Institute of Mutagenesis and Differentiation, Pisa (IT)
Bibliographic Reference: Article: Mutation Research Letters, Vol. 323 (1994) pp. 127-131
Record Number: 199410833 / Last updated on: 1994-11-28
Category: PUBLICATION
Original language: en
Available languages: en