3-isobutyl-1-methylxanthine inhibits the mutagenic activity of 7,12-dimethylbenz[a]anthracene in epithelial liver cells in culture
The mutagenic activity of 7,12-dimethylbenz[a]anthracene in epithelial liver cells (CHEL) in culture was unaffected by the enhancement of intracellular cAMP induced to different extents and with different mechanisms by forskolin and 3-isobutyl-1-methylxanthine. However, the latter compound exerted antimutagenic effects (greater than 60 %), which may be tentatively ascribed to inhibition of the inducible monooxygenase isoforms(s) responsible for the specific biotransformation of 7,12-dimethylbenz[a]anthracene to highly mutagenic metabolites in CHEL cells.
Bibliographic Reference: Article: Mutation Research Letters, Vol. 323 (1994) pp. 127-131
Record Number: 199410833 / Last updated on: 1994-11-28
Original language: en
Available languages: en