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Deoxycoformycin (DCF) is a powerful inhibitor of adenosine deaminase by virtue of its immunosuppressive action and has found clinical application for the treatment of several types of lymphatic leukaemia. This study concentrates on the cytotoxicity of DCF in combination with deoxyAdo on two human colon carcinoma (LOVO and HT29) and Chinese hamster ovary (CHO K-1) cell lines. The different sensitivities of the three cell lines to DCF are related to their distinct purine salvage enzyme pattern.

Additional information

Authors: CAMICI M, Università di Pisa, Dipartimento di Fisiologia e Biochimica (IT);TURRIANI M, Università di Pisa, Dipartimento di Fisiologia e Biochimica (IT);TURCHI G, JRC Ispra (IT);TOZZI M G, Università di Sassari, Istituto di Chimica Biologica (IT);COS J ET AL., Universitat de Barcelona, Facultat de Farmacia, Unitat de Bioquimica (ES)
Bibliographic Reference: Paper presented: 8th International Symposium on Purine and Pyrimidine Metabolism, Blomington (US), May 22-27, 1994
Availability: Available from (1) as Paper EN 38386 ORA
Record Number: 199410860 / Last updated on: 1994-11-28
Original language: en
Available languages: en
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