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An experimental study of the biological effectiveness of multi-fractionated low doses of high-LET radiation was carried out using BC3F(1) male mice. They were treated with whole-body irradiation with five equal daily fractions of fission neutrons to yield cumulative doses of 0.025, 0.05, 0.10, 0.17, 0.25, 0.36, 0.535 and 0.71 Gy at the RSV-TAPIRO reactor (mean neutron energy 0.4 MeV, in terms of kerma, y(D) = 51.5 keV/micron, dose rate 0.004 Gy/min) and were followed for their entire life span. A statistical method was applied to establish the existence of a carcinogenic effect in long-term animal experiments, for myeloid leukaemia and for the presence of selected solid tumours. Tumour occurrence was evaluated further as final incidences with age adjustment for the differences in mortality rates. Survival and incidence data for selected classes of tumours showed no marked overall influence of the time regime of neutron irradiation on survival and tumour induction.

Additional information

Authors: DI MAJO V ET AL., ENEA, Centro Ricerche Energia Frascati, Roma (IT)
Bibliographic Reference: Article: Radiation Research, Vol. 138 (1994) pp. 252-259
Record Number: 199410988 / Last updated on: 1994-11-28
Original language: en
Available languages: en