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Abstract

This report investigates the ability of dithiocarbamate fungicides thiram and ziram to induce chromosomal aberrations in Chinese hamster ovary (CHO) cells both in the absence and presence of S9 metabolism, and in Chinese hamster epithelial liver (CHEL) cells which retain metabolic competence to activate different classes of procarcinogens. A literature survey indicates the genotoxic potential for both thiram and ziram, and several mutagenicity short term tests have been carried out to investigate this aspect of the fungicides. The results obtained indicate thiram and ziram are potential clastogens in the CHEL and CHO cells in the presence of S9 metabolism, and require metabolic conversion to become genetically active. This corroborates the evidence that CHEL cells are suitable to activate and detect a broad spectrum of chemical procarcinogens.

Additional information

Authors: MOSESSO P, Università della Tuscia, Dipartimento di Agrobiologia e Agrochimica, Viterbo (IT);PALITTI F, Università della Tuscia, Dipartimento di Agrobiologia e Agrochimica, Viterbo (IT);CINELLI S, Research Toxicology Centre, Pomezia (IT);DI CHIARA D, Research Toxicology Centre, Pomezia (IT);FIORE M, Università "La Sapienza", Roma (IT);TURCHI G, JRC Ispra (IT)
Bibliographic Reference: Article: Teratogenesis, Carcinogenesis, and Mutagenesis, Vol. 14 (1994) pp. 145-155
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