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This report is an evaluation of the cytotoxic and genetic effects induced by the fungicides tetramethylthiuram disulfide (thiram) and zinc dimethyldithiocarbamate (ziram) on epithelial liver cells in culture. Also studied is the inhibitory activity of the two dithiocarbamates on superoxide dismutase (SOD) and catalase using EPR spectra. Thiram and ziram were cytotoxic but not mutagenic in metabolically competent liver cells. Ziram was more effective in inhibiting SOD and catalase. EPR studies showed that the differential chelating activity exhibited by the fungicides towards transition metal ions dislocated in the active site of the enzymes may be the mechanism of the observed inhibition.

Additional information

Authors: SBRANA M, Istituto di Mutagenesi e Differenziamento del CNR, Pisa (IT);BERTACCA A, Istituto di Mutagenesi e Differenziamento del CNR, Pisa (IT);PELLEGRINO M, Università di Pisa, Dipartimento di Scienze dell'Ambiente e del Territorio (IT);PINZINO C, Istituto di Chimica Quantistica ed Energetica Molecolare del CNR, Pisa (IT);TURCHI G, JRC Ispra (IT)
Bibliographic Reference: Paper presented: 24th Annual Meeting of Human Biomonitoring in Assessment of Genetic Risk, Poznan (PL), August 31 - September 3, 1994
Availability: Available from (1) as Paper EN 38375 ORA
Record Number: 199411280 / Last updated on: 1994-12-06
Original language: en
Available languages: en